Synthesis and characterization of new acid-functionalized porphyrins displaying antimicrobial activity against gram positive bacteria, yeasts and filamentous fungi with or without ultra-high irradiance - Institut Agro Dijon Accéder directement au contenu
Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2024

Synthesis and characterization of new acid-functionalized porphyrins displaying antimicrobial activity against gram positive bacteria, yeasts and filamentous fungi with or without ultra-high irradiance

Résumé

The antimicrobial activity of new acid-functionalized porphyrins, with or without ultra-high irradiance, was investigated. Antibacterial efficacy was evaluated against Staphylococcus aureus (methicillin-resistant or methicillin-sensitive strains) and antifungal efficacy was evaluated against the yeast Candida albicans and the filamentous fungi Aspergillus fumigatus. Overall, the porphyrins tested are more effective against S. aureus. The best results were obtained with zinc diacid porphyrins 4 and 5 after only 3 min of ultra-high irradiation (500 mW/cm2, 405 nm), demonstrating that acid-functionalized porphyrins are promising as novel antimicrobial drugs for surface disinfection.

Dates et versions

hal-04628600 , version 1 (28-06-2024)

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Marc Sautour, Thibaut Théry, Gaëlle Divoux, Sébastien Dupont, Laurent Beney, et al.. Synthesis and characterization of new acid-functionalized porphyrins displaying antimicrobial activity against gram positive bacteria, yeasts and filamentous fungi with or without ultra-high irradiance. Bioorganic and Medicinal Chemistry, 2024, 109, pp.117810. ⟨10.1016/j.bmc.2024.117810⟩. ⟨hal-04628600⟩
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