Article Dans Une Revue Science Advances Année : 2021

Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle

Alexandre Prola
Marie Maurer
Guillaume Courtin
Serge Luquet
Laurent Tiret

Résumé

Unbalanced energy partitioning participates in the rise of obesity, a major public health concern in many countries. Increasing basal energy expenditure has been proposed as a strategy to fight obesity yet raises efficiency and safety concerns. Here, we show that mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis display increased basal energy expenditure and protection against high-fat diet–induced obesity. Mechanistically, muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of the inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and adenosine 5′-triphosphate (ATP) synthase, which was restored by cardiolipin enrichment. Our study reveals that selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level.
Fichier principal
Vignette du fichier
eabd6322.full.pdf (2.74 Mo) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-03105418 , version 1 (26-01-2021)

Identifiants

Citer

Alexandre Prola, Jordan Blondelle, Aymeline Vandestienne, Jérôme Piquereau, Raphaël Denis, et al.. Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle. Science Advances , 2021, 7 (1), pp.eabd6322. ⟨10.1126/sciadv.abd6322⟩. ⟨hal-03105418⟩
379 Consultations
236 Téléchargements

Altmetric

Partager

More