This Special Issue of Annals of Regional Science collects selected papers from the 17th International Workshop on Spatial Econometrics and Statistics, held in Dijon (France) on May 24–25, 2018. Organized by the LEDi (University of Burgundy) and the CESAER (INRAE, AgroSup Dijon), this edition followed previous workshops held in France since 2001 (Avignon, Besançon, Dijon, Grenoble, Orléans, Paris, Strasbourg, Toulon, Toulouse and Avignon). The aim of this international workshop is to promote and develop scientific exchanges between economists, econometricians, statisticians, geographers, ecologists, agronomists and mathematicians on spatial econometrics and statistics and their applications in several fields. This workshop also aims to discuss the state of the art and future challenges as well as opportunities in the fields of spatial econometrics and statistics and encourage exchanges between senior and junior researchers involved in spatial statistics and econometrics.