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Dernières publications
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
132
Publications avec texte intégral
Open Access
52 %
Mots clés
GABA
Myotonic Dystrophy
Skeletal muscle
Neuron
Gene Therapy
Dystrophie Myotonique
BIOLOGIE MOLECULAIRE
Duchenne muscular dystrophy
Mouse models
RNA interference
Alternative splicing
Brain
ARN
Central nervous system
Myostatin
Glial cells
Humans
Mice
Animals
Astrocytes
Therapy
Gene therapy
Trinucleotide Repeat Expansion
Transgenic mouse
RNA biology
Quantitative microdialysis
Male
Exercise
Muscle
CONGENITAL MYATHENIC SYNDROME
Dystrophin
CRISPR/Cas9
Intermediate filament
Heart
Trinucleotide repeat expansion
PacBio
Acetylcholinesterase knockout mouse
Glutamate
Acetylcholinesterase deficiency
Dystrophie myotonique
DMSXL mice
Myotonic dystrophy type 1
Antisense oligonucleotides
CTG repeat contractions
Muscular dystrophy
DM1
Desmin
Dilated cardiomyopathy
Transcriptomics
Fibrosis
Genotype phenotype correlation
Motoneuron
Astrocyte
Acute coronary syndrome
Expression
Transgenic mouse model
Knockout
Maximal force
RNA splicing
Cytoskeleton
Myelin
MBNL
Glucocorticoid-receptor
AAV
Cell model
Myotonic dystrophy mouse models
CRISPRi
Aging
Thérapie génique
Brain dysfunction
Autophagy
PCR
Myotonic Dystrophy type 1
KNOCKOUT MICE
In vivo
Glucocorticoids
CTG repeat instability
ACETYLCHOLINESTERASE
Cardiac muscle
Oligodendrocyte
Mouse model
Cell penetrating peptide
DMPK
Heart failure
Dynamin 2
Gene editing
CMS
CTG repeats
GSK3
Lc3
Antisense oligonucleotide
Diaphragm
Oligodendrocytes
Myotonic dystrophy
Hypoxia
Centronuclear myopathy
Myotonic Dystrophy Type 1
Exercice
Cell culture model
Long read sequencing