Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis. - Institut Agro Dijon Accéder directement au contenu
Article Dans Une Revue Plant Cell Reports Année : 2014

Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.

Corinne Lefort
  • Fonction : Auteur
  • PersonId : 1170554

Résumé

Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and progression of fibrosis along with adipocyte metabolic dysfunction and death. Adipose tissue fibrosis is attenuated by macrophage depletion. Impairment of Toll-like receptor 4 signaling protects mice from obesity-induced fibrosis. The presence of a functional Toll-like receptor 4 on adipose tissue hematopoietic cells is necessary for the initiation of adipose tissue fibrosis. Continuous low-dose infusion of the Toll-like receptor 4 ligand, lipopolysaccharide, promotes adipose tissue fibrosis. Ex vivo, lipopolysaccharide-mediated induction of fibrosis is prevented by antibodies against the profibrotic factor TGFβ1. Together, these results indicate that obesity and endotoxemia favor the development of adipose tissue fibrosis, a condition associated with insulin resistance, through immune cell Toll-like receptor 4.

Domaines

Immunologie
Fichier principal
Vignette du fichier
1-s2.0-S2211124714002599-main.pdf (2.77 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

inserm-00991860 , version 1 (16-05-2014)

Identifiants

Citer

Isabelle K Vila, Pierre-Marie Badin, Marie-Adeline Marques, Laurent Monbrun, Corinne Lefort, et al.. Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.. Plant Cell Reports, 2014, 7 (4), pp.1116-29. ⟨10.1016/j.celrep.2014.03.062⟩. ⟨inserm-00991860⟩
854 Consultations
372 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More