%0 Journal Article %T Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice %+ Dynamique Musculaire et Métabolisme (DMEM) %+ Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM) %+ Lipides - Nutrition - Cancer [Dijon - U1231] (LNC) %+ Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM) %+ Czech Academy of Sciences [Prague] (CAS) %+ Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN) %A Benlebna, Melha %A Balas, Laurence %A Bonafos, Béatrice %A Pessemesse, Laurence %A Vigor, Claire %A Grober, Jacques %A Bernex, Florence %A Fouret, Gilles %A Paluchova, Veronika %A Gaillet, Sylvie %A Landrier, Jean %A Kuda, Ondrej %A Durand, Thierry %A Coudray, Charles %A Casas, François %A Feillet-Coudray, Christine %Z Algerian Ministry of Higher Education and Scientific Research %Z French Lipid Nutrition Group %Z National Institute for Agronomic Research %Z Grant Agency of the Czech Republic %Z Human Nutrition Department (Alim-H department) %< avec comité de lecture %@ 0955-2863 %J Journal of Nutritional Biochemistry %I Elsevier %V 79 %P 108361 %8 2020-05 %D 2020 %R 10.1016/j.jnutbio.2020.108361 %M 32179409 %K FAHFA %K Inflammation %K Insulin sensitivity %K Liver fibrosis %K Liver steatosis %K Mice %Z Life Sciences [q-bio]/Human health and pathologyJournal articles %X Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a new family of endogenous lipids recently discovered. Several studies reported that some FAHFAs have antidiabetic and anti-inflammatory effects. The objective of this study was to explore the impact of two FAHFAs, 9-PAHPA or 9-OAHPA, on the metabolism of mice. C57Bl/6J male mice, 6 weeks old, were divided into 3 groups of 10 mice each. One group received a control diet and the two others groups received the control diet supplemented with 9-PAHPA or 9-OAHPA for 12 weeks. Mouse weight and body composition were monitored throughout the study. Some days before euthanasia, energy expenditure, glucose tolerance and insulin sensitivity were also determined. After sacrifice, blood and organs were collected for relevant molecular, biochemical and histological analyses. Although high intake of 9-PAHPA or 9-OAHPA increased basal metabolism, it had no direct effect on body weight. Interestingly, the 9-PAHPA or 9-OAHPA intake increased insulin sensitivity but without modifying glucose tolerance. Nevertheless, 9-PAHPA intake induced a loss of glucose-stimulated insulin secretion. Surprisingly, both studied FAHFAs induced hepatic steatosis and fibrosis in some mice, which were more marked with 9-PAHPA. Finally, a slight remodeling of white adipose tissue was also observed with 9-PAHPA intake. In conclusion, the long-term high intake of 9-PAHPA or 9-OAHPA increased basal metabolism and insulin sensitivity in healthy mice. However, this effect, highly likely beneficial in a diabetic state, was accompanied by manifest liver damage in certain mice that should deserve special attention in both healthy and pathological studies. %G English %2 https://institut-agro-dijon.hal.science/hal-02532921/document %2 https://institut-agro-dijon.hal.science/hal-02532921/file/HAL2020_Benlebna%20J%20Nutr%20Biochem%202020_healthy%20mice_masque.pdf %L hal-02532921 %U https://institut-agro-dijon.hal.science/hal-02532921 %~ INSERM %~ UNIV-BOURGOGNE %~ CNRS %~ UNIV-AMU %~ ENSC-MONTPELLIER %~ IBMM %~ FNCLCC %~ VALDAURELLE %~ INC-CNRS %~ LNC-UMR866 %~ AGREENIUM %~ BS %~ CHIMIE %~ AGROSUP-DIJON %~ UNIV-MONTPELLIER %~ DMEM %~ IRCM %~ INRAE %~ TEST-HALCNRS %~ INRAEOCCITANIEMONTPELLIER %~ PHASE %~ INCIAM %~ UM-2015-2021 %~ TEST2-HALCNRS %~ TEST3-HALCNRS %~ INSTITUT-AGRO-DIJON %~ INSTITUT-AGRO-DIJON-LNC %~ INSTITUT-AGRO-LNC %~ ALIMH