%0 Journal Article %T Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging %+ Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB) %+ Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB) %+ Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon) %+ Equipe NuTox (LNC - U1231) (NUTOX) %+ Plateforme d'imagerie préclinique [Centre Georges-François Leclerc] (CGFL) %A Thomas, Guillaume %A Boudon, Julien %A Maurizi, Lionel %A Moreau, Mathieu %A Walker, Paul %A Séverin, Isabelle %A Oudot, Alexandra %A Goze, Christine %A Poty, Sophie %A Vrigneaud, Jean-Marc %A Demoisson, Frédéric %A Denat, Franck %A Brunotte, François %A Millot, Nadine %< avec comité de lecture %@ 2470-1343 %J ACS Omega %I ACS Publications %V 4 %N 2 %P 2637-2648 %8 2019-02-05 %D 2019 %R 10.1021/acsomega.8b03283 %K Imaging agents %K Nanoparticles %K Nanostructures %K Tomography %Z Life Sciences [q-bio]/Biotechnology %Z Life Sciences [q-bio]/Bioengineering/ImagingJournal articles %X Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (-NH2 and -COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further ⁶⁴Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r2 and r2∗ (T2 and T2∗ relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI. %G English %2 https://institut-agro-dijon.hal.science/hal-02068644/document %2 https://institut-agro-dijon.hal.science/hal-02068644/file/2019%20acsomega.8b03283.pdf %L hal-02068644 %U https://institut-agro-dijon.hal.science/hal-02068644 %~ INSERM %~ UNIV-BOURGOGNE %~ CNRS %~ UNIV-BM %~ ICB %~ ICMUB %~ FNCLCC %~ CGFL %~ UNIV-BM-THESE %~ INC-CNRS %~ LNC-UMR866 %~ AGREENIUM %~ LNC-NUTOX %~ AGROSUP-DIJON %~ TEST-HALCNRS %~ TEST2-HALCNRS %~ INSTITUT-AGRO-DIJON %~ INSTITUT-AGRO-DIJON-LNC %~ INSTITUT-AGRO-LNC